Dating back to the early 1800s, an isolated family in eastern Kentucky - who can trace their roots back to a French orphan - started producing children who were blue.
The mystery surrounding a 19th century family whose inbred children had blue skin has been solved.
Through a combination of recessive genes and inbreeding, the children of the Fugate family suffered from a condition called methaemoglobinaemia which limits the carrying of oxygen to the blood and renders the skin blue in colour. "They weren’t sick; it was just the way they look," said nurse Ruth Pendergrass.
Source Daily Mail